Troponin I

A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

Also Known As:

Troponin I1; Troponin I2; Troponin I3; Troponin-I

Macromolecular Substances: 97
- Polymers: 13051
  - Biopolymers: 773
    - Microfilament Proteins: 486
      - Troponin: 6812
        Troponin I: 4805
- Multiprotein Complexes: 125
  - Troponin: 6812
    - Troponin I: 4805
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cytoskeletal Proteins: 739
    - Microfilament Proteins: 486
      - Troponin: 6812
        Troponin I: 4805
  - Contractile Proteins: 699
    - Muscle Proteins: 1582
      - Troponin: 6812
        Troponin I: 4805

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